解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Mutations in High temperature requirement A2 (HtrA2), also designated PARK13, which lead to the loss of its protease activity, have been associated with Parkinson's disease (PD). HtrA2 is a mitochondrial protease that translocates to the cytosol upon the initiation of apoptosis where it participates in the abrogation ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2016-0069
更新日期:2017-01-01 00:00:00
abstract::Complex chromosome rearrangements (CCRs) are defined as structural abnormalities involving more than two chromosome breaks, coupled with exchanges of chromosomal segments. Information on CCRs in plants is limited. In the present study, a plant (26-4) harboring translocation chromosomes 1RS.1BL and 4RS.4DL was selected...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2016-0112
更新日期:2016-12-01 00:00:00
abstract::Environmental DNA (eDNA) is emerging as a potentially powerful tool for inferring species' presence, and hence occupancy, from DNA that is shed into environmental samples such as water. Although eDNA screening has been used to detect DNA from a variety of taxonomic groups, it has not yet been used to identify DNA from...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0196
更新日期:2016-12-01 00:00:00
abstract::Stenotrophomonas maltophilia is a global multidrug-resistant human opportunistic pathogen in clinical environments. Stenotrophomonas maltophilia is also ubiquitous in aqueous environments, soil, and plants. Various molecular typing methods have revealed that S. maltophilia exhibits high levels of phenotypic and genoty...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2016-0073
更新日期:2016-12-01 00:00:00
abstract::The early life-history stages of fishes are poorly known, impeding acquisition of the identifications needed to monitor larval recruitment and year-class strength. A comprehensive database of COI sequences, linked to authoritatively identified voucher specimens, promises to change this situation, representing a signif...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0212
更新日期:2016-11-01 00:00:00
abstract::The "rings" belonging to the genus Ypthima are amongst the most common butterflies in Peninsular Malaysia. However, the species can be difficult to tell apart, with keys relying on minor and often non-discrete ring characters found on the hindwing. Seven species have been reported from Peninsular Malaysia, but this is...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0156
更新日期:2016-10-01 00:00:00
abstract::High-throughput sequencing (HTS) of DNA barcodes (metabarcoding), particularly when combined with standardized sampling protocols, is one of the most promising approaches for censusing overlooked cryptic invertebrate communities. We present biodiversity estimates based on sequencing of the cytochrome c oxidase subunit...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0208
更新日期:2016-09-01 00:00:00
abstract::During 30 years of unprecedented urbanization, plant diversity in Shenzhen, a young megacity in southern China, has increased dramatically. Although strongly associated with plant diversity, butterfly diversity generally declines with urbanization, but this has not been investigated in Shenzhen. Considering the speed ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0192
更新日期:2016-09-01 00:00:00
abstract::Copines are evolutionarily conserved calcium-dependent membrane-binding proteins with potentially critical biological functions. In plants, the function of these proteins has not been analyzed except for in Arabidopsis thaliana where they play critical roles in development and disease resistance. To facilitate functio...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2016-0015
更新日期:2016-08-01 00:00:00
abstract::Bambara groundnut (Vigna subterranea (L.) Verdc.) is an indigenous underutilized legume that has the potential to improve food security in semi-arid Africa. So far, there are a lack of reports of controlled breeding populations that could be used for variety development and genetic studies. We report here the construc...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0153
更新日期:2016-07-01 00:00:00
abstract::Genome size is an indicator of evolutionary distance and a metric for genome characterization. Here, we report accurate estimates of genome size in 99 accessions from 26 species of Avena. We demonstrate that the average genome size of C genome diploid species (2C = 10.26 pg) is 15% larger than that of A genome species...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0132
更新日期:2016-03-01 00:00:00
abstract::We sequenced the complete mitochondrial (mt) genome of Camponotus atrox (Hymenoptera: Formicidae), which is only distributed in Korea. The genome was 16 540 bp in size and contained typical sets of genes (13 protein-coding genes, 22 tRNAs, and 2 rRNAs). The C. atrox A+T-rich region, at 1402 bp, was the longest of all ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0080
更新日期:2016-01-01 00:00:00
abstract::Multiple reaction monitoring mass spectrometry (MRM-MS) is an emerging technology for blood biomarker verification and validation; however, the results may be influenced by pre-analytical factors. This exploratory study was designed to determine if differences in phlebotomy techniques would significantly affect the ab...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0036
更新日期:2015-12-01 00:00:00
abstract::Much effort has been directed at identifying sources of resistance to Fusarium head blight (FHB) in wheat. We sought to identify molecular markers for what we hypothesized was a new major FHB resistance locus originating from the wheat cultivar 'Freedom' and introgressed into the susceptible wheat cultivar 'USU-Apogee...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0088
更新日期:2015-11-01 00:00:00
abstract::The present work compares the molecular affinities, revealed by GISH, with the analysis of meiotic pairing in intra- and interspecific hybrids between species of Zea obtained in previous works. The joint analysis of these data provided evidence about the evolutionary relationships among the species from the paleopolyp...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2015-0081
更新日期:2015-10-01 00:00:00
abstract::Intermediate wheatgrass (Thinopyrum intermedium (Host) Barkworth & D.R. Dewey), a segmental autoallohexaploid (2n = 6x = 42), is not only an important forage crop but also a valuable gene reservoir for wheat (Triticum aestivum L.) improvement. Throughout the scientific literature, there continues to be disagreement as...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2014-0186
更新日期:2015-02-01 00:00:00
abstract::Basic helix-loop-helix (bHLH) proteins are highly conserved DNA-binding transcription factors of a large superfamily. Animal bHLH proteins play important regulatory roles in various developmental processes such as neurogenesis, myogenesis, heart development, and hematopoiesis. The jewel wasp (Nasonia vitripennis) is a...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2014-0171
更新日期:2014-10-01 00:00:00
abstract::Ginkgo biloba L. (known as ginkgo or maidenhair tree) is a phylogenetically isolated, charismatic, gymnosperm tree. Herbal dietary supplements, prepared from G. biloba leaves, are consumed to boost cognitive capacity via improved blood perfusion and mitochondrial function. A novel DNA mini-barcode assay was designed a...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2014-0130
更新日期:2014-09-01 00:00:00
abstract::Cytological descriptions are given for two sympatric sibling species, Simulium praelargum IIIL-st and Simulium praelargum IIIL-1.2, from Darjeeling, West Bengal, India. Sibling IIIL-1.2 differs from IIIL-st by a two step fixed included inversion (IIIL-1.2) found on the long arm of chromosome III. Both siblings possess...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2014-0025
更新日期:2014-04-01 00:00:00
abstract::The wild olive distribution extends from the Mediterranean region to south Asia and Austral Africa. The species is also invasive, particularly in Australia. Here, we investigated the sequence variation at five nuclear single-copy genes in 41 native and invasive accessions of the Mediterranean and African olive subspec...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2014-0001
更新日期:2014-03-01 00:00:00
abstract::Phyllomys (Echimyidae, Rodentia) is a genus of Neotropical rodents with available cytogenetic data restricted to six out of 13 species, mainly based on simple staining methods, without detailed analyses. In this work, we present new karyotypes for Phyllomys lamarum (diploid number 2n = 56, fundamental number or number...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2013-0168
更新日期:2014-01-01 00:00:00
abstract::Despite the recent advances in plant population genetic studies, the lack of information regarding pedigree, ploidy level, or mode of inheritance for many polyploids can compromise the analysis of the molecular data produced. The aim of this study was to examine both microsatellite and cytogenetic characteristics of t...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2013-0159
更新日期:2013-12-01 00:00:00
abstract::Genetic variation in Gir cattle (Bos indicus) has so far not been well characterized. In this study, we used whole genome sequencing of three Gir bulls and a pooled sample from another 11 bulls to identify polymorphisms and loci under selection. A total of 9 990 733 single nucleotide polymorphisms (SNPs) and 604 308 i...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2013-0082
更新日期:2013-10-01 00:00:00
abstract::Species of the genus Lilium are well known for their large genomes. Although expansion of noncoding repeated DNA is believed to account for this genome size, retroelement del Ty3-gypsy is the only one described so far in the genus Lilium. We isolated Ty1-copia elements from Lilium longiflorum and named them LIREs (lil...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2013-0088
更新日期:2013-09-01 00:00:00
abstract::Plant disease resistance gene analog (RGA) markers were designed according to the conserved sequence of known RGAs and used to map resistance genes. We used genome-wide RGA markers for genetic analyses of structure and diversity in a global rice germplasm collection. Of the 472 RGA markers, 138 were polymorphic and th...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2012-0142
更新日期:2013-07-01 00:00:00
abstract::Changes in chromosome number have played an important role in the evolution of the genus Trifolium. Along with a few species of polyploid origin there are several cases of dysploidy as evidenced by the presence of four basic chromosome numbers (x = 8, 7, 6, 5). Trifolium subterraneum and Trifolium israeliticum are rel...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2013-0055
更新日期:2013-06-01 00:00:00
abstract::The aim of this study was to investigate the differential expression characteristics and the roles of the genome-wide microRNAs (miRNAs) in immunoglobulin A nephropathy (IgAN) kidney tissues. We used Illumina high-throughput sequencing technology to evaluate the miRNAs expression of six biopsy tissues from IgAN and si...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2012-0159
更新日期:2013-03-01 00:00:00
abstract::Rhubarb (official Da-huang) is an important medicinal herb in Asia. Many adulterants of official Da-huang have been discovered in Chinese markets in recent years, which has resulted in adverse effects in medicinal treatment. Here, novel molecular markers based on a short maturase K (matK) gene were developed for authe...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2012-0182
更新日期:2013-02-01 00:00:00
abstract::Elymus repens (L.) Gould (2n = 6x = 42, StStStStHH) is a hexaploid perennial wheatgrass species from the tribe Triticeae, distantly related to bread wheat Triticum aestivum L. (2n = 6x = 42, AABBDD). As a potential source of resistance to Fusarium head blight (FHB), E. repens was crossed to common wheat to transfer re...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/gen-2012-0130
更新日期:2013-01-01 00:00:00
abstract::A genetic linkage map of Brassica rapa L. was constructed using recombinant inbred lines (RILs) derived from a cross between yellow-seeded cultivar Sampad and a yellowish brown seeded inbred line 3-0026.027. The RILs were evaluated for seed color under three conditions: field plot, greenhouse, and controlled growth ch...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g2012-066
更新日期:2012-12-01 00:00:00
abstract::The family Pinaceae is made up mostly of diploid species (2n = 24). Systematization of karyotype analysis was developed to make comparison of intra- and interspecific karyotypes among the Pinaceae more accurate and reliable. Considering all parameters, the genera Pseudotsuga and Pseudolarix have the "most derived" (or...
journal_title:Genome
pub_type: 杂志文章,评审
doi:10.1139/g2012-061
更新日期:2012-11-01 00:00:00
abstract::The wheat-alien small segment translocation (SAST) lines carrying the beneficial genes from wild species are useful genetic stocks for wheat improvement. In this study, to introduce the grain hardness-related genes of Haynaldia villosa (L.) Schur. into common wheat (Triticum aesitivum L.), the mature female gametes of...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g2012-051
更新日期:2012-09-01 00:00:00
abstract::Trigeneric hybrids offer opportunities to transfer alien traits into cultivated wheat. In this study, a new trigeneric hybrid involving species of Triticum, Psathyrostachys, and Thinopyrum was synthesized by crossing Triticum aestivum L. (wheat)--Thinopyrum intermedium (Host) Barkworth & D.R. Dewey amphiploid Zhong 3 ...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g2012-025
更新日期:2012-05-01 00:00:00
abstract::In an initial investigation of differential expression of genes caused by cis-acting regulatory elements in rice, the lack of reproducibility led us to question the basic premise of allelic expression imbalance determination: namely that departures of cDNA expression ratios from those observed in genomic DNA provide u...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g2012-023
更新日期:2012-05-01 00:00:00
abstract::The first doubled haploid oat linkage map constructed at MTT Agrifood Research Finland was supplemented with additional microsatellites and Diversity Array Technology (DArT) markers to produce a map containing 1058 DNA markers and 34 linkage groups. The map was used to locate quantitative trait loci (QTLs) for 11 impo...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g2012-017
更新日期:2012-04-01 00:00:00
abstract::The nearly complete mitochondrial (mt) genome of an egg parasitoid, Trissolcus basalis (Wollaston), was sequenced using both 454 and Illumina next-generation sequencing technologies. A portion of the noncoding region remained unsequenced, possibly owing to the presence of repeats. The sequenced portion of the genome i...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g2012-005
更新日期:2012-03-01 00:00:00
abstract::Carrot (Daucus carota L.) chromosomes are small and poorly differentiated in size and morphology. Here we demonstrate that fluorescent in situ hybridization (FISH) signals derived from arbitrary PCR probes can be used for chromosome identification in carrot. To prepare probes, we searched for nonpolymorphic products a...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g2012-003
更新日期:2012-03-01 00:00:00
abstract::Cosmology and evolution together have enabled us to look deep into the past and comprehend evolution-from the big bang to the cosmos, from molecules to humans. Here, I compare the nature of theories in biology and physics and ask why physical theories get accepted by the public without necessarily comprehending them b...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g11-046
更新日期:2011-10-01 00:00:00
abstract::Elymus L. is the largest and most complex genus in the Triticeae tribe of grasses with approximately 150 polyploid perennial species occurring worldwide. We report here the first genetic linkage map for Elymus. Backcross mapping populations were created by crossing caespitose Elymus wawawaiensis (EW) (Snake River whea...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g11-045
更新日期:2011-10-01 00:00:00
abstract::European hazelnut (Corylus avellana L.) is the only economically important nut crop in the family Betulaceae. Because of its small genome size (~385 Mb / 1C), relatively short life cycle, availability of a dense linkage map, and amenability to transformation by Agrobacterium, the European hazelnut could serve as a mod...
journal_title:Genome
pub_type: 杂志文章
doi:10.1139/g11-048
更新日期:2011-10-01 00:00:00